Chemotherapy-Induced Nausea and Vomiting Management

Efficacy and Administration

• The National Comprehensive Cancer Network recommends that a fixed combination of an NK1 receptor antagonist and a 5-HT3 receptor antagonist, such as Akynzeo, provides complete protection for both immediate and delayed nausea/vomiting after chemotherapy, eliminating the need for additional antiemetic pills on days 2-5 1
• The combination of netupitant and palonosetron in Akynzeo is effective in preventing chemotherapy-induced nausea and vomiting, with common adverse events including headache and constipation, which are typically mild 2

Management of Breakthrough Nausea

• The National Comprehensive Cancer Network suggests that if breakthrough nausea or vomiting occurs despite taking Akynzeo as prescribed, rescue medications from different drug classes may be added rather than repeating Akynzeo 3
• Adjustment of the antiemetic regimen may be necessary for subsequent chemotherapy cycles to ensure optimal prevention of nausea and vomiting 4