Timing of CNS Stimulant Administration

Comparison with Other Stimulants

• The National Comprehensive Cancer Network recommends that methylphenidate or dextroamphetamine for daytime sedation should have a second dose given at lunch, preferably no later than 2:00 PM 1, 2
• The National Comprehensive Cancer Network suggests that caffeine's last dose should be given no later than 4:00 PM to minimize interference with sleep patterns 1, 2
• The American Academy of Family Physicians recommends that bupropion's second dose should be given before 3 PM to minimize insomnia risk 3

Cardiovascular Considerations

• The American Heart Association implies that attempting to extend Vyvanse's effects into the evening through timing manipulation could lead to unpredictable cardiovascular stress, as the medication already increases heart rate and blood pressure 4