Promethazine Use in Pregnancy and Safety Considerations

Guideline Recommendations for Antiemetic Use in Pregnancy

• The obstetric guideline recommends promethazine as a first‑line anti‑emetic for nausea and vomiting in pregnancy, using a dose of 12.5–25 mg administered every 4–8 hours via oral, intramuscular, or intravenous routes; this aligns with FDA dosing recommendations. 1, 2

Contraindications and Precautions

• Promethazine should be avoided in patients with narrow‑angle glaucoma, prostatic hypertrophy, or bladder‑neck obstruction because of its anticholinergic effects. 3