Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 9/5/2025

Guidelines for Adrenaline Packing During Tonsillectomy

  • The American Society of Anesthesiologists recommends a multimodal analgesic regimen with paracetamol and NSAIDs as baseline therapy for patients undergoing tonsillectomy 4
  • The Anaesthesia society recommends a single intra-operative dose of IV dexamethasone for its analgesic and anti-emetic effects in patients undergoing tonsillectomy 1, 4
  • Recent studies and meta-analyses have found no increased bleeding risk with NSAIDs in patients undergoing tonsillectomy 3
  • Pre-operative gabapentinoids may be considered as an alternative to NSAIDs in patients with contraindications, according to the Anaesthesia society 3, 4
  • Intra-operative IV ketamine or dexmedetomidine can be considered as second-line options, but should be used cautiously due to potential side effects, as recommended by the Anaesthesia society 3, 4

Adrenaline Use in Tonsillectomy: Evidence and Concerns

  • The Anaesthesia society does not recommend peritonsillar infiltration or topical application of local anesthetics, including adrenaline, due to concerns of serious side effects 1
  • The PROSPECT guidelines specifically list local anesthetic infiltration as not recommended for pain management in tonsillectomy, as stated by the Anaesthesia society 2

Surgical Technique Considerations

  • Current guidelines cannot recommend a specific surgical technique to influence post-tonsillectomy pain, as most studies evaluate surgical techniques based on bleeding risk and cost-effectiveness rather than pain outcomes, according to the Anaesthesia society 3
  • Coblation techniques may have slightly less postoperative pain during the first day compared with cold dissection and electrocautery techniques, as found by the Anaesthesia society 1

Important Considerations and Pitfalls

  • Tonsillar infiltration may not be as safe as infiltration in other areas due to the neurovascular bundle in the vicinity, explaining the high potential for side effects, as noted by the Anaesthesia society 3
  • Adequate hydration should be maintained throughout the perioperative period, as recommended by the Praxis Medical Insights society 5
  • Monitoring for signs of inadequate pain control is essential, as poor pain management may lead to inadequate oral intake and dehydration, according to the Praxis Medical Insights society 4