Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 9/4/2025

Medications and Diarrhea

Medication-Induced Diarrhea

  • Methenamine hippurate (Hiprex) is not a commonly reported side effect to cause diarrhea, according to the American Urological Association guidelines 1

Management of Diarrhea

  • For patients experiencing diarrhea, the American Society of Clinical Oncology recommends monitoring for improvement when taking medications like Gemtesa with food, and discussing alternative medications with a provider if symptoms are severe or persistent 2
  • The American Gastroenterological Association suggests that loperamide can be used for symptomatic relief of diarrhea, and maintaining adequate hydration is crucial to prevent dehydration 2
  • Severe diarrhea persisting more than 48 hours despite management requires medical attention, as recommended by the American College of Gastroenterology 2